Anti-Z-DNA/Z-RNA [Z22]
Product Sizes
1 mg
AB00783-1-1-BT-1MG
About this Product
- SKU:
- AB00783-1-1-BT
- Additional Names:
- Z-22; Z 22; Z DNA; ZDNA; Z RNA; ZRNA; Z NA; Z-NA; ZNA
- Application:
- Cell-based/Functional Assay, ELISA, Flow Cytometry, Gel Shift/EMSA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Surface Plasmon Resonance, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- Z22
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Mouse
- Immunogen:
- Z22 was prepared by immunizing C57BL/6 mice with brominated poly(dG-dC).poly(dG-dC) complexed with methylated bovine serum albumin (BSA), and was selected for by ELISA. Brominated poly(dG-dC).poly(dG-dC) forms a stable Z-DNA helix under physiological salt conditions.
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Wide/Non-species Specific
- Shipping Conditions:
- Blue Ice
- Specificity:
- Z22 binds both Z-DNA, but not B-DNA or ssDNA (single-stranded DNA). It recognizes Z-DNA at the phosphodiester backbone of various base sequence including (dG-dC)n.(dG-dC)n, (dTdG)n.(dC-dA)n, (dG-dme5C)n.(dG-dme5C)n and (dG-dbr5C)n.(dG-dbr5C)n. In other words, Z22 binds Z-DNA irrespective of sequence. Z22 Also binds DNA-8-MOP aducts and Z-RNA.
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab00783-1.1-BT
