Anti-trans-sialidase [13G9]
Product Sizes
100 ug
AB00762-1-6-100UG
About this Product
- SKU:
- AB00762-1-6
- Additional Names:
- TS
- Application:
- Block/Inhibit/Neutralise, Crystallization, Immunofluorescence
- Buffer:
- PBS with 0.02% Proclin 300.
- translate.label.attr.clone:
- 13G9
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS with 0.02% Proclin 300.
- Host:
- Mouse
- Immunogen:
- 13G9 was prepared by immnuizing mice with recombinant TS (D Delta1443TS), which is fully active but includes a deletion of a non-neutralizing epitope (speeds up production of neutralizing antibodies). The antibody was selected for by screening using a TS-inhibition assay.
- Purification:
- Purified
- Reactivities:
- Parasite/Protozoa
- Shipping Conditions:
- Blue Ice
- Specificity:
- 13G9 is a neutralizing antibody which binds specifically and with high affinity (KD ~0.72 nM) to a conformational epitope on the Trypanosoma cruzi TS protein - the antibody binds to TS in such a way as to prevent the movement of Y119, whose mobility has a key role in the trans-glycosidase mechanism. Specificity of binding was deduced by the absence of reactivity against TS from the closely related
- Storage Conditions:
- 2-8[o]C Aliquot., -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab00762-1.6
