Anti-Prion protein [VRQ14]
Product Sizes
1 mg
AB00752-23-0-BT-1MG
About this Product
- SKU:
- AB00752-23-0-BT
- Additional Names:
- CD230; PrP scrapie-senstive variant VRQ; PrP; major prion protein
- Application:
- Crystallization, ELISA, Immunoprecipitation
- Buffer:
- PBS
- translate.label.attr.clone:
- VRQ14
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Rabbit
- Immunogen:
- The VRQ14 antibody was prepared by immunizing Prnp0/0 mice with the C-terminal domain of recombinant ovine VRQ variant prion protein. The Fab fragemnt was produced by digestion with papain.
- Isotype:
- IgG
- Purification:
- Purified
- Reactivities:
- Sheep
- Shipping Conditions:
- Blue Ice
- Specificity:
- VRW14 binds to both PrPC (host prion protein) and to PrPSc (pathogenic isoform of the prion protein) - the epitope of the antibody mainly consists of PrP residues 188-199 (C-terminal part of helix H2 and N-terminal part of the H2-H3 loop). Misfolding and aggregation of mutated protein PrP leads to prion diseases which are associated with the conversion of the A Alpha-helix rich prion protein (PrPC
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab00752-23.0-BT
