Anti-Thrombopoietin [TN1 ]
Product Sizes
200 ug
AB00746-1-1-200UG
About this Product
- SKU:
- AB00746-1-1
- Additional Names:
- C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; TPO
- Application:
- Block/Inhibit/Neutralise, Crystallization, ELISA
- Buffer:
- PBS with 0.02% Proclin 300.
- translate.label.attr.clone:
- TN1
- Clonality:
- Recombinant Monoclonal
- Formulation:
- PBS with 0.02% Proclin 300.
- Host:
- Mouse
- Immunogen:
- TN1 was prepared by immunizing BALB/c mice by intraperitoneal injecction of recombinant human TPO. The Fab fragment was produced via incubation with papain which cleaves at the hinge region of the IgG to remove the Fc region. The product is then subsequently incubated under reducing conditions and the free Cys residue blocked with iodoacetamide.
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- TN1 binds specifically to TPO at an epitope which consists of residues from the C-terminal end of helix C (R98) and the C-D crossover loop (residues 102-115) and residues from the C-terminal half of helix B (residues 57-61) (PMID: 14769915). TPO is a heavily glycosylated cytokine which acts as the ligand for the hematopoietic receptor c-Mpl. The primary role of TPO is as a regulator of megakaryocy
- Storage Conditions:
- 2-8[o]C Aliquot., -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab00746-1.1
