Anti-SIRP g [OX-119]
Product Sizes
5 mg
AB00589-10-6-BS-5MG
About this Product
- SKU:
- AB00589-10-6-BS
- Additional Names:
- CD172g; OX119; MRC OX-119; MRC OX119; SIRP-g; SIRPg; SIRP gamma; SIRP-gamma; CD172 antigen-like family member B; signal-regulatory protein beta; CD172-g
- Application:
- Block/Inhibit/Neutralise, ELISA, Flow Cytometry, Immunoprecipitation
- Buffer:
- PBS
- translate.label.attr.clone:
- OX-119
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- OX-119 was prepared by immunizing BALB/c mice with a chimeric protein made up of human SIRPg and a leader peptide of rat CD4 domain (SIRPg-CD4 ).
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Hybridoma supernatants were initially screened by ELISA, using SIRPg-CD4, human SIRPa-Fc, human SIRPb-Fc or CD4 to eliminate hybridomas with cross-reactivity to rat CD4, human SIRPa, and SIRPb. There is some marginal binding of OX-119 to SIRPb transfected 293T cells. SIRPg binds CD47. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells resul
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab00589-10.6-BS
