Anti-EGFR [Matuzumab]
Product Sizes
1 mg
AB00534-10-3-BT-1MG
About this Product
- SKU:
- AB00534-10-3-BT
- Additional Names:
- ErbB-1; ERBB1; HER1; EGF; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EMD72000; mAb425; 425; mAb 425
- Application:
- Block/Inhibit/Neutralise, ELISA, Flow Cytometry, Immunofluorescence, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- Matuzumab
- Clonality:
- Recombinant Monoclonal
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- The parental mouse antibody was generated by immunizing BALB/c mice intraperitoneally with A431 cells in phosphate buffered saline (PBS). Later on the humanzied version of the antibody was created by grafting CDRs of the murine antibody onto human constant regions.
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds the extracellular domain III of the human EGFR and does not cross react with murine EGFR. It was also reported that residues S460/G461 in EGFR domain III are essential components of the epitope. This antibody binds at a site distinct from the EGF binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand bindi
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab00534-10.3-BT
