Anti-Citrullinated collagen type II [ACC4]
Product Sizes
1 mg
AB00224-23-0-BT-1MG
About this Product
- SKU:
- AB00224-23-0-BT
- Additional Names:
- ACPA; CII; Col II; COL2A1; citrullinated CII; citrullinated Col II; Col C II; citrullinated proteins; antibodies against citrullinated proteins; Collagen alpha-1(II) chain; Alpha-1 type II collagen; C1 epitope of citrullinated collagen type II as an a-chain peptide
- Application:
- ELISA, IHC-Frozen
- Buffer:
- PBS
- translate.label.attr.clone:
- ACC4
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Formulation:
- PBS only.
- Host:
- Rabbit
- Immunogen:
- The original antibody was generated by immunizing a DBA/1 or (B10.Q xDBA/1) F1 mouse with calcium-dependent peptidyl arginine deiminase (PAD4) treated helical CII peptides containing T and B cell epitopes emulsified in CFA.
- Isotype:
- IgG
- Purification:
- Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody binds the citrullinated C1 epitope (amino acids 359 - 369 : ARGLTGRPGDA) as an A Alpha-chain peptide of the collagen type II and also shows binding affinity for the cyclic citrullinated filaggrin peptide. C1 peptide contains two arginines which are post translationally converted to citrulline. ACC4 was found to recognize the first citrulline at position 360. This antibody does not cr
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab00224-23.0-BT
