Anti-HSP40; Hdj1 Monoclonal Antibody (Clone : 3B9.E6) - RPE
Product Sizes
100 µg
£603.00
42-1287-100UG
About this Product
- SKU:
- 42-1287
- Additional Names:
- DNAJB1||DNAJ1||HDJ1||HSPF1
- translate.label.attr.clone:
- 3B9.E6
- Clonality:
- Monoclonal
- Conjugate:
- RPE
- Extra Details:
- Human HSP40/DnaJ proteins comprise a large protein family; members of which feature the J domain (named after the bacterial DnaJ protein). The J-domain spans the first 75 N-terminal amino acids and is separated from the C-terminal by a glycine/phenylalanine-rich domain. Members of the HSP40/DnaJ family play diverse roles in many cellular processes; such as folding; translocation; degradation and assembly of multi-protein complexes. In particular; Hdj1; the first human HSP40/DnaJ protein identified; plays an important role in protein translation and folding; as well as in the regulation of HSP70 function. HSP40 stimulates the ATPase activity of HSP70 which in turn causes conformational changes of the unfolded proteins. The HSP40-HSP70-unfolded protein complex further binds to co-chaperones Hip; Hop and HSP90 which leads to protein folding; or components of protein degradation machinery CHIP and BAG-1. Some studies have shown that the difference between HDJ1 and type 1 DNAJ proteins including HDJ2 and yeast YdjI is the result of the possession of a zinc finger domain by the latter; which helps in the function of protein folding.
- Host:
- Mouse
- Immunogen:
- Recombinant Protein HSP40 (Hdj1)
- Isotype:
- Mouse IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
