Anti-HPV16 E1/E4 (Human Papilloma Virus 16) Monoclonal Antibody(Clone: HPV16 E1/E4)

Product Sizes

20 µg

£397.00

36-3796-20UG

100 µg

£716.00

36-3796-100UG

About this Product

SKU:: 36-3796
Additional Names:: HPV-16; HPV-16 capsid; HPV16 L1; HPV16 major capsid protein L1; Human papillomavirus type 16 L1; Human papillomavirus type 16 major capsid protein L1
translate.label.attr.clone:: HPV16 E1/E4
Clonality:: Monoclonal
Extra Details:: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16; a 'high-risk' sexually-transmitted HPV that can lead to cervical; anal; vulvar; head; neck; and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification; but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle; and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse.
Host:: Mouse
Immunogen:: Recombinant human HPV16 E1/E4 fragment (aa 36-41).
Isotype:: Mouse IgG1; kappa
Shipping Conditions:: Blue Ice
Storage Conditions:: Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
Supplier:: Abeomics
Type:: Antibodies:Monoclonal Antibody

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