Anti-Myofibroblast Marker Monoclonal Antibody(Clone: PR 2D3)
Product Sizes
20 µg
£397.00
36-3718-20UG
100 µg
£716.00
36-3718-100UG
About this Product
- SKU:
- 36-3718
- translate.label.attr.clone:
- PR 2D3
- Clonality:
- Monoclonal
- Extra Details:
- Myofibroblasts are a unique group of smooth muscle-like fibroblasts that play an important role in oncogenesis; inflammation; repair; wound contraction and fibrosis. Like smooth muscle (SM) cells; myofibroblasts contain microfilament bundles and express -SM Actin; the Actin isoform that is present in myoepithelial cells and SM cells and especially abundant in vascular SM cells. Myofibroblasts secrete inflammatory and anti-inflammatory cytokines; chemokines; growth factors and lipid and gaseous inflammatory mediators; as well as extracellular matrix proteins and proteases in most organs and tissues. Besides being temporarily present following tissue injuries and fibrocontractive diseases; myofibroblasts are also present under normal conditions in regions such as the skin; pulmonary septa and periodontal ligaments. Stem cell factor and platelet-derived growth factor (PDGF) are two secreted proteins responsible for differentiating myofibroblasts from embryological stem cells. PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts.
- Host:
- Mouse
- Immunogen:
- Crude homogenate of normal human colorectal mucosa
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
