Anti-Cytochrome P450 3A1 / CYP3A1 Monoclonal Antibody(Clone: P6)
Product Sizes
20 µg
£397.00
36-3717-20UG
100 µg
£716.00
36-3717-100UG
About this Product
- SKU:
- 36-3717
- Additional Names:
- CYP3A1; Cytochrome P450 family 3 subfamily A polypeptide 1
- translate.label.attr.clone:
- P6
- Clonality:
- Monoclonal
- Extra Details:
- Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related; but distinct; oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound; either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver; these substrates include toxins; drµgs; and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies; the CYP1 family is involved in drµg metabolism and includes 3 subfamilies; 3 genes and 1 pseudogene. The CYP2 family are part of the microsomal drµg metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids; fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates; glucocorticoids and rifampicin. P6 is highly specific for members of the CYP 3A gene family and cross reacts with CY 3A4 in human; CYP 3A in rat and potentially CYP 3A11 (based on inducibility) in mice.
- Host:
- Mouse
- Immunogen:
- Full length protein (Rat). Rat liver cytochrome P450 3A1.
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
