Anti-Cig2 Monoclonal Antibody(Clone: 3A11/5)
Product Sizes
20 µg
£397.00
36-3714-20UG
100 µg
£716.00
36-3714-100UG
About this Product
- SKU:
- 36-3714
- Additional Names:
- B type S phase cyclin antibody
- translate.label.attr.clone:
- 3A11/5
- Clonality:
- Monoclonal
- Extra Details:
- Cig2 is a cyclin that functions as the catalytic subunit of cyclin-dependent kinases (Cdks) in the fission yeast Schizosaccharomyces pombe. It is a B-type; S phase cyclin that is required for both the G1/S and G2/M cell cycle transitions and is expressed in a sharp spike that peaks during the G1/S period. Cig2 binds to Cdc2 (Cdk); and the resulting Cdc2/Cig2 complex controls the G1/S transition of the cell cycle. Disruption of Cig2 delays the onset of mitosis. The expression of the Cig2 gene is dependent on Mlu1-binding factor (MBF); and the protein is destroyed during anaphase by the APC/cyclosome (APC/C) and Skp1/Cullin-1/F-box (SCF); thereby ensuring the spike expression pattern of Cig2. SCF regulates Cig2 levels in a dual manner; transcriptionally and post-translationally; while APC/C only destroys the protein.
- Host:
- Mouse
- Immunogen:
- Bacterial S. pombe Cig2 Purified protein.
- Isotype:
- Mouse IgG1; kappa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
