Anti-GITR / Tnfrsf18 (Mouse) Monoclonal Antibody(Clone: DTA-1)
Product Sizes
20 µg
£397.00
36-3688-20UG
100 µg
£716.00
36-3688-100UG
About this Product
- SKU:
- 36-3688
- Additional Names:
- Activation-inducible TNF-alphaelated ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-alphaelated ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18
- translate.label.attr.clone:
- DTA-1
- Clonality:
- Monoclonal
- Extra Details:
- GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-alphaeceptor superfamily; also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to aµgment T cell activation; proliferation; cytokine production as well as MAPKs and NF-B activation; and abrogate the inhibitory function ofCD25+CD4+Tregs. In vivoactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
- Host:
- Rat
- Immunogen:
- Mouse CD25+ CD4+ T cells
- Isotype:
- Rat IgG2b; lambda
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
