Anti-Major Vault Protein (MVP) Monoclonal Antibody(Clone: 1014)
Product Sizes
20 µg
£397.00
36-3670-20UG
100 µg
£716.00
36-3670-100UG
About this Product
- SKU:
- 36-3670
- Additional Names:
- Lung resistance-related protein (LRP); Major Vault Protein; MVP; VAULT1
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 104kDa-110kDa; characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology; including several small molecules of RNA; but a single protein species. The MVP accounts for 70% of their mass. Their shape is reminiscent of the nucleopore central plµg. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen; progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
- Host:
- Mouse
- Immunogen:
- proteins precipitated from human breast cancer MCF-7 cells
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
