Anti-CD40/ TNFRSF5 / CD40L-Receptor Monoclonal Antibody(Clone: C40/2383)
Product Sizes
20 µg
£397.00
36-3608-20UG
100 µg
£716.00
36-3608-100UG
About this Product
- SKU:
- 36-3608
- Additional Names:
- B-cell surface antigen CD40; Bp50; CD40; CD40L receptor; GP39; HIGM1; IGM; IMD3; p50; TBAM; TNF receptor superfamily member 5; TNFRSF5; TRAP
- translate.label.attr.clone:
- C40/2383
- Clonality:
- Monoclonal
- Extra Details:
- CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching; memory B cell development; and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand; which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation; and thus is thoµght to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes; follicular dendritic cells; bone marrow-derived dendritic cells; thymic epithelium; and interdigitating cells in the T-cell zones of secondary lymphoid organs.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human CD40 protein (around aa 29-107) (exact sequence is proprietary)
- Isotype:
- Mouse IgG2b; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
