Anti-CD33 / SIGLEC3 (Myeloid Cell Surface Antigen) Monoclonal Antibody(Clone: WM53)-CF488
Product Sizes
0.5 at 100 ml at µg/ml
£716.00
36-3584-0.5AT100MLATUG
About this Product
- SKU:
- 36-3584
- Additional Names:
- gp67; My9; Myeloid cell surface antigen CD33; p67; Sialic acid-binding Ig-like lectin 3 (SIGLEC3)
- translate.label.attr.clone:
- WM53
- Clonality:
- Monoclonal
- Conjugate:
- CF488
- Extra Details:
- Recognizes a 67kDa glycoprotein; which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage; binds sialic acid residues in N- and O-glycans on cell surfaces; and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors; monocytes; granulocytes; dendritic cells and mast cells. It is absent on platelets; lymphocytes; erythrocytes and hematopoietic stem cells.
- Host:
- Mouse
- Immunogen:
- Human AML cells
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 4 to 8[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
