Anti-CD163 (Monocyte & Macrophage Marker) Monoclonal Antibody(Clone: M130/1210)
Product Sizes
20 µg
£397.00
36-3551-20UG
100 µg
£716.00
36-3551-100UG
About this Product
- SKU:
- 36-3551
- Additional Names:
- CD163; CD163 antigen; Macrophage-associated antigen; M130; CD163 molecule; Hemoglobin scavenger receptor; MM130; Scavenger receptor cysteine rich type 1 protein M130
- translate.label.attr.clone:
- M130/1210
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a protein of 140kDa; identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages; histiocytes with high expression.Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis; where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes); gut; Kupffer cells; a few alveolar macrophages; macrophages in the placenta; and in macrophages in inflamed tissues including tumor tissue.
- Host:
- Mouse
- Immunogen:
- Recombinant human CD163 fragment (around aa 43-196) (Exact sequence is proprietary)
- Isotype:
- Mouse IgG2b; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
