Anti-Cyclin B1 (G2- & M-phase Cyclin) Monoclonal Antibody(Clone: V92.1)
Product Sizes
20 µg
£397.00
36-3443-20UG
100 µg
£716.00
36-3443-100UG
About this Product
- SKU:
- 36-3443
- Additional Names:
- CCNB; CCNB1; CCNB1_HUMAN; G2 Mitotic Specific Cyclin B1
- translate.label.attr.clone:
- V92.1
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a protein of 55-62kDa; identified as cyclin B1. In mammals; cyclin B associates with inactive p34cdc2; which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis; when Cdc25; a specific protein phosphatase; dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So; cyclin B-p34cdc2 plays a critical role in G2 to M transition.
- Host:
- Mouse
- Immunogen:
- Hamster Cyclin B1 protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
