Anti-Calpastatin Monoclonal Antibody(Clone: CAST/1550)
Product Sizes
20 µg
£397.00
36-3416-20UG
100 µg
£716.00
36-3416-100UG
About this Product
- SKU:
- 36-3416
- Additional Names:
- BS 17; Calpain inhibitor; Calpastatin; Cast; Heart type calpastatin; Sperm BS 17 component
- translate.label.attr.clone:
- CAST/1550
- Clonality:
- Monoclonal
- Extra Details:
- Calpastatin is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal; calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion; mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits; designated Calpastatin; Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types; tissue type and erythrocyte type; resulting from both alternative splicing and proteolytic processing. Calpastatin co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization; such as the acrosome reaction.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human CAST protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
