Anti-Alpha Actinin 4 / ACTN4 Monoclonal Antibody(Clone: 93)
Product Sizes
20 µg
£397.00
36-3407-20UG
100 µg
£716.00
36-3407-100UG
About this Product
- SKU:
- 36-3407
- Additional Names:
- F-actin cross-linking protein; Focal segmental glomerulosclerosis 1 (FSG1); Non-muscle alpha-actinin-4
- Clonality:
- Monoclonal
- Extra Details:
- The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins; dystrophins and -actinins. There are four tissue-specific -actinins; namely -actinin-1; -actinin-2; -actinin-3 and -actinin-4; which are localized to muscle and non-muscle cells; including skeletal; cardiac and smooth muscle cells; as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain; two calponin-homology domains; two EF-hand domains and four spectrin repeats; throµgh which they function as bundling proteins that can cross-link F-Actin; thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1); a common renal lesion characterized by decreasing kidney function and; ultimately; renal failure.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human ACTN4 protein
- Isotype:
- Mouse IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
