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Antibodies

Anti-ZAP70 (Chronic Lymphocytic Leukemia Marker) Monoclonal Antibody(Clone: ZAP70/2047)

Product Sizes
20 µg
£397.00
36-3383-20UG
100 µg
£716.00
36-3383-100UG
About this Product
SKU:
36-3383
Additional Names:
Selective T cell defect; SRK; STD; Syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70;TZK; Zeta chain associated protein kinase 70kDa
translate.label.attr.clone:
ZAP70/2047
Clonality:
Monoclonal
Extra Details:
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
Host:
Mouse
Immunogen:
Recombinant fragment (around aa 247-382) of human ZAP70 protein (exact sequence is proprietary)
Isotype:
Mouse IgG1; kappa
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig. 2: SDS-PAGE Analysis Purified ZAP70 Mouse Monoclonal Antibody (ZAP70/2047). Confirmation of Integrity and Purity of Antibody.
Fig. 3: Flow Cytometric Analysis of PFA-fixed Jurkat cells. ZAP70 Mouse Monoclonal Antibody (ZAP70/2047) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).
Fig. 4: Immunofluorescence staining of paraformaldehyde-fixed Jurkat cells with ZAP70 Mouse Monoclonal Antibody (ZAP70/2047) followed by goat anti-Mouse IgG-CF488 (Green). Nuclei are labeled with Reddot (Red).
Fig. 4: Immunofluorescence staining of paraformaldehyde-fixed Jurkat cells with ZAP70 Mouse Monoclonal Antibody (ZAP70/2047) followed by goat anti-Mouse IgG-CF488 (Green). Nuclei are labeled with Reddot (Red).
Fig. 5: Analysis of Protein Array containing more than 19;000 full-length human proteins using ZAP70 Mouse Monoclonal Antibody (ZAP70/2047). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that arr