Anti-Thymidylate Synthase (5-FU Resistance Marker) Monoclonal Antibody(Clone: rTYMS/1884)
Product Sizes
20 µg
£397.00
36-3324-20UG
100 µg
£716.00
36-3324-100UG
About this Product
- SKU:
- 36-3324
- Additional Names:
- dTMP synthase; TMS; TS; TSase; TYMS protein; Tyms thymidylate synthetase
- translate.label.attr.clone:
- rTYMS/1884
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a protein of 36kDa; identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP); which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines; an important group of antineoplastic drµgs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5;10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal; gastric; head and neck; and breast carcinomas.
- Host:
- Mouse
- Immunogen:
- Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
