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Antibodies

Anti-Thymidylate Synthase (5-FU Resistance Marker) Monoclonal Antibody(Clone: TYMS/1884)

Product Sizes
20 µg
£397.00
36-3323-20UG
100 µg
£716.00
36-3323-100UG
About this Product
SKU:
36-3323
Additional Names:
dTMP synthase; TMS; TS; TSase; TYMS protein; Tyms thymidylate synthetase
translate.label.attr.clone:
TYMS/1884
Clonality:
Monoclonal
Extra Details:
It recognizes a protein of 36kDa; identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP); which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines; an important group of antineoplastic drµgs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5;10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal; gastric; head and neck; and breast carcinomas.
Host:
Mouse
Immunogen:
Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
Isotype:
Mouse IgG2c; kappa
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8[o]C. Antibody is stable for 24 months. Non-hazardous.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig. 2: SDS-PAGE Analysis Purified Thymidylate Synthase Mouse Monoclonal Antibody (TYMS/1884). Confirmation of Purity and Integrity of Antibody.
Fig. 3: Western Blot Analysis of human HeLa cell lysate using Thymidylate Synthase Mouse Monoclonal Antibody (TYMS/1884).
Fig. 4: Immunofluorescence Analysis of PFA-fixed Ramos cells labeling PU.1 with Thymidylate Synthase Mouse Monoclonal Antibody (TYMS/1884) followed by Goat anti-Mouse IgG-CF488 (Green). Membrane is labeled with Phalloidin (Red).
Fig. 4: Immunofluorescence Analysis of PFA-fixed Ramos cells labeling PU.1 with Thymidylate Synthase Mouse Monoclonal Antibody (TYMS/1884) followed by Goat anti-Mouse IgG-CF488 (Green). Membrane is labeled with Phalloidin (Red).
Fig. 5: Flow Cytometric Analysis of PFA-fixed MOLT4 cells. Thymidylate Synthase Monospecific Mouse Monoclonal Antibody followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).