Anti-TSH-Receptor; A-Chain (Thyroid Marker) Monoclonal Antibody(Clone: SPM223)
Product Sizes
20 µg
£397.00
36-3316-20UG
100 µg
£716.00
36-3316-100UG
About this Product
- SKU:
- 36-3316
- Additional Names:
- CHNG1; hTSHRI; LGR3; Thyroid-stimulating hormone receptor; Thyrotropin receptor; Thyrotropin receptor I; TSHR
- translate.label.attr.clone:
- SPM223
- Clonality:
- Monoclonal
- Extra Details:
- Thyroid-stimulating hormone (TSH; also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism; which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR); which is cleaved into two subunits; A and B; and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease; an autoimmune disorder; TSHR is activated by autoantibodies; which may be stimulated by the cleavage of the A and B subunits.
- Host:
- Mouse
- Immunogen:
- Recombinant human TSHR; A-Chain protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
