Anti-TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker) Monoclonal Antibody(Clone: TRAF1/2770)
Product Sizes
20 µg
£397.00
36-3312-20UG
100 µg
£716.00
36-3312-100UG
About this Product
- SKU:
- 36-3312
- Additional Names:
- EBI6; EBV induced protein 6; Epstein-Barr virus-induced protein 6; TNF receptor-associated factor 1; TRAF1
- translate.label.attr.clone:
- TRAF1/2770
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a protein of 52kDa; which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30% of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Althoµgh the two entities overlap clinically; histopathologically; immunopathologically and genetically; they differ considerably in their prognosis. In particular; common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However; both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously; whereas those of cALCL persist and may progress and spread. Moreover; LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach; in contrast to patients with cALCL. Besides; LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR)-associated factor 1); a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84%) show a strong TRAF1 expression; tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7%). Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human TRAF1 protein (around aa 73-219) (exact sequence is proprietary)
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
