Anti-TPO (Thyroid Peroxidase) (Thyroid Marker) Monoclonal Antibody(Clone: TPO/1922)
Product Sizes
20 µg
£397.00
36-3306-20UG
100 µg
£716.00
36-3306-100UG
About this Product
- SKU:
- 36-3306
- Additional Names:
- MSA; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX
- translate.label.attr.clone:
- TPO/1922
- Clonality:
- Monoclonal
- Extra Details:
- Thyroperoxidase (TPO) is a 933-amino acid; type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones; thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis; including congenital hypothyroidism; congenital goiter; and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human TPO (around aa 685-804) (Exact sequence is proprietary)
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
