Anti-pS2 / pNR-2 / TFF1 (Estrogen-Regulated Protein) Monoclonal Antibody(Clone: TFF1/2969R)
Product Sizes
20 µg
£397.00
36-3233-20UG
100 µg
£716.00
36-3233-100UG
About this Product
- SKU:
- 36-3233
- Additional Names:
- BCEI; Breast Cancer Estrogen Inducible Protein; Gastrointestinal Trefoil Protein; Gastrointestinal trefoil protein pS2; HP1A; HPS2; pNR2; TFF1; Trefoil Factor 1
- translate.label.attr.clone:
- TFF1/2969R
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a polypeptide of 6.5kDa; identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throµghout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds; forming the trefoil motif; or P-domain. pS2 is known to form dimers and this dimerization is thoµght to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic; often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa; gastric fluid; goblet cells in the colon and small intestine; and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
