Anti-Tal1 Monoclonal Antibody(Clone: TAL1/3146)
Product Sizes
20 µg
£397.00
36-3227-20UG
100 µg
£716.00
36-3227-100UG
About this Product
- SKU:
- 36-3227
- Additional Names:
- bHLHa17; Class A basic helix-loop-helix protein 17; OTTHUMP00000009563; OTTHUMP00000009564; SCL; STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR; Stem cell protein; T cell acute lymphocytic leukemia 1; T cell acute lymphocytic leukemia 1 protein; T cell acute lymphocytic leukemia 1 protein; T
- translate.label.attr.clone:
- TAL1/3146
- Clonality:
- Monoclonal
- Extra Details:
- Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia; making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition; leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase II; a serine/threonine protein kinase known to modulate the activity of other HLH transcription factors.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length TAL1 protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
