Anti-STAT6 (Solitary Fibrous Tumor Marker) Monoclonal Antibody(Clone: STAT6/2410)
Product Sizes
20 µg
£397.00
36-3221-20UG
100 µg
£716.00
36-3221-100UG
About this Product
- SKU:
- 36-3221
- Additional Names:
- IL4 STAT; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal transducer and activator of transcription 6; STAT interleukin4 induced; STAT6; Transcription factor IL 4 STAT
- translate.label.attr.clone:
- STAT6/2410
- Clonality:
- Monoclonal
- Extra Details:
- STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently sµggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion; formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13; in 55-100% of solitary fibrous tumors; regardless of tumor morphology or anatomical site. By immunohistochemistry; nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges; including meningioma; glioblastoma; gliosarcoma; haemangioblastoma; schwannoma and haemangioma. A recent study by Cheah; et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested; regardless of histology; anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative; demonstrating 100% specificity.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human STAT6 protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
