Anti-Spastin Monoclonal Antibody(Clone: Sp 3G11-1)
Product Sizes
20 µg
£397.00
36-3184-20UG
100 µg
£716.00
36-3184-100UG
About this Product
- SKU:
- 36-3184
- Additional Names:
- ADPSP; FSP2; Spast; Spatin; SPG4
- translate.label.attr.clone:
- Sp 3G11-1
- Clonality:
- Monoclonal
- Extra Details:
- The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility; membrane trafficking; proteolysis; protein folding and organelle biogenesis. Spastin; a member of the AAA protein family; is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm; where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST; SPG4) cause the most common form of spastic paraplegia 4; an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent; retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40% of all autosomal dominant HSPs.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human Spastin protein.
- Isotype:
- Mouse IgG2a; kappa
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
