Anti-SOX10 (Melanoma Marker) Monoclonal Antibody(Clone: SOX10/991)
Product Sizes
20 µg
£397.00
36-3178-20UG
100 µg
£716.00
36-3178-100UG
About this Product
- SKU:
- 36-3178
- Additional Names:
- DOM; PCWH; SOX10; SRY (sex determining region Y) box 10; SRY box containing gene 10; SRY related HMG box gene 10; Waardenburg syndrome type 2E(WS2E); WS4; Waardenburg syndrome type 4C (WS4C)
- translate.label.attr.clone:
- SOX10/991
- Clonality:
- Monoclonal
- Extra Details:
- The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array; containing more than 19;000; full-length human proteins. Recognizes a protein of ~55kDa; identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain; which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma; including conventional; spindled; and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes; but not by other lymph node components such as dendritic cells; which usually express S100 protein. Commonly used melanoma markers; such as anti-HMB-45 and anti-Melan-A; are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues; it is expressed in Schwann cells; melanocytes; and myoepithelial cells of salivary; bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
- Host:
- Mouse
- Immunogen:
- Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietary)
- Isotype:
- Mouse IgG2b; kappa
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
