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Antibodies

Anti-SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Monoclonal Antibody(Clone: SOX4/2540)

Product Sizes
20 µg
£397.00
36-3172-20UG
100 µg
£716.00
36-3172-100UG
About this Product
SKU:
36-3172
Additional Names:
SOX; SRY (sex determining region Y) box 4; SRY box containing gene 4; SRY related HMG box gene 4; Transcription factor SOX-4
translate.label.attr.clone:
SOX4/2540
Clonality:
Monoclonal
Extra Details:
SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart; pancreas; brain; and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types; and increased SOX4 activity contributes to cellular transformation; cell survival; and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF-alpha-induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival invitro and for primary tumor growth and metastasis invivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.
Host:
Mouse
Immunogen:
Recombinant full-length human SOX4 protein
Isotype:
Mouse IgG2b; kappa
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig. 2: Formalin-fixed; paraffin-embedded human Breast Carcinoma stained with SOX4 Mouse Monoclonal Antibody (SOX4/2540).
Fig. 3: SDS-PAGE Analysis Purified SOX4 Mouse Monoclonal Antibody (SOX4/2540). Confirmation of Purity and Integrity of Antibody.
Fig. 4: Analysis of Protein Array containing more than 19;000 full-length human proteins using SOX4 Mouse Monoclonal Antibody (SOX4/2540). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array
Fig. 4: Analysis of Protein Array containing more than 19;000 full-length human proteins using SOX4 Mouse Monoclonal Antibody (SOX4/2540). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array