Anti-SIGLEC1 / CD169 / Sialoadhesin Monoclonal Antibody(Clone: HSn 7D2)
Product Sizes
20 µg
£397.00
36-3164-20UG
100 µg
£716.00
36-3164-100UG
About this Product
- SKU:
- 36-3164
- Additional Names:
- CD169; CD169 antigen; Sialic acid binding immunoglobulin like lectin 1; Sialic acid-binding Ig-like lectin 1; Sialoadhesin; Siglec-1; SN
- translate.label.attr.clone:
- HSn 7D2
- Clonality:
- Monoclonal
- Extra Details:
- Two families of mammalian lectin-like adhesion molecules; the selectins and the sialoadhesins; bind glycoconjµgate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins; designated siglecs or sialoadhesins; are immunoglobulin superfamily members that recognize sialylated ligands. The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The human Siglec-1 gene maps to chromosome 20p13 and encodes a 1;709 amino acid protein; also known as CD169. Alternative splicing of the Siglec-1 gene produces a variant; encoding a type I transmembrane protein isoform that is soluble rather than membrane-bound. Studies have shown human Siglec-1 has greater affinity for Neu5Ac over Neu5Gc. Siglec-1 is a sialic acid-binding receptor that is expressed in hemopoietic cells. It mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages; sinus-lining cells and reticulum cells.
- Host:
- Mouse
- Immunogen:
- Fc fusion protein containing N-terminal 4 domains of human sialoadhesin.
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
