Anti-Calcineurin B homologous protein 2 / HCC Antigen 520 Monoclonal Antibody(Clone: CPTC-CHP2-1)
Product Sizes
20 µg
£397.00
36-3141-20UG
100 µg
£716.00
36-3141-100UG
About this Product
- SKU:
- 36-3141
- Additional Names:
- calcineurin-like EF hand protein 2; calcineurin-like EF-hand protein 2; HCA520; hepatocellular carcinoma antigen gene 520; Hepatocellular carcinoma-associated antigen 520 homolog
- translate.label.attr.clone:
- CPTC-CHP2-1
- Clonality:
- Monoclonal
- Extra Details:
- CHP2 (calcineurin B homologous protein 2); also known as hepatocellular carcinoma-associated antigen 520; is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1; CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Thoµgh not typically detected in normal tissues; CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B; CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length CHP2 protein
- Isotype:
- Mouse IgG2c; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
