Anti-Calcineurin B / PPP3R1 Monoclonal Antibody(Clone: BE2.1)
Product Sizes
20 µg
£397.00
36-2996-20UG
100 µg
£716.00
36-2996-100UG
About this Product
- SKU:
- 36-2996
- Additional Names:
- calcineurin B; type I (19kDa); Calcineurin subunit B type 1; CALNB1; Cna2; CNB; CNB1; Ppp3r1; protein phosphatase 3 (formerly 2B); regulatory subunit B; 19kDa; alpha isoform (calcineurin B; type I)
- translate.label.attr.clone:
- BE2.1
- Clonality:
- Monoclonal
- Extra Details:
- Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues; but its levels are highest in the brain; where it may play a role in learning and memory. It has many substrates; including NFAT; a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human Calcineurin B protein
- Isotype:
- Mouse IgG2a; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
