Anti-DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Monoclonal Antibody(Clone: DG1/1486)
Product Sizes
20 µg
£397.00
36-2989-20UG
100 µg
£716.00
36-2989-100UG
About this Product
- SKU:
- 36-2989
- Additional Names:
- Anoctamin 1; Calcium Activated Chloride Channel; Discovered On Gastrointestinal Stromal Tumors Protein 1; TAOS2; ORAOV2; TMEM16A
- translate.label.attr.clone:
- DG1/1486
- Clonality:
- Monoclonal
- Extra Details:
- Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's); c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors; which; due to appearance; may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's; including all c-kit negative GIST's. Overexpression of DOG-1 has been sµggested to aid in the identification of GISTs; including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.
- Host:
- Mouse
- Immunogen:
- Recombinant human DOG-1 protein fragment (around aa 2-101) (exact sequence is proprietary)
- Isotype:
- Mouse IgG2b; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
