Anti-EGLN1 / PHD2 Monoclonal Antibody(Clone: 366G/76/3)
Product Sizes
20 µg
£397.00
36-2977-20UG
100 µg
£716.00
36-2977-100UG
About this Product
- SKU:
- 36-2977
- Additional Names:
- Chromosome 1 Open Reading Frame 12 (C1ORF12); DKFZp761F179; ECYT3; Egl 9 family hypoxia inducible factor 1; Egl nine homolog 1; Egln1; HIF Prolyl Hydroxylase 2 (HIF PH2); HIFPH2; HPH2; Hypoxia inducible factor prolyl hydroxylase 2; ORF13; P4H2; PhD2; PNAS 118; PNAS 137; Prolyl hydroxylase domain-con
- translate.label.attr.clone:
- 366G/76/3
- Clonality:
- Monoclonal
- Extra Details:
- 366G/76/3 recognises human prolyl hydroxylase 2 (PHD2); a 46kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex; consisting of an alpha and beta subunit; which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions; the alpha subunit of HIF-1 is rapidly degraded; however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit; thereby targeting this subunit for degradation.
- Host:
- Mouse
- Immunogen:
- Residues 1-24 of PHD2
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
