Anti-RNA Polymerase II Monoclonal Antibody(Clone: CTD4H8)
Product Sizes
20 µg
£397.00
36-2953-20UG
100 µg
£716.00
36-2953-100UG
About this Product
- SKU:
- 36-2953
- Additional Names:
- DNA-directed RNA polymerase II largest subunit RNA polymerase II 220kd subunit; DNA-directed RNA polymerase II subunit RPB1; hRPB220; hsRPB1; POLR2; Polr2a; POLRA; Polymerase (RNA) II (DNA directed) polypeptide A 220kDa; RNA polymerase II subunit B1; RPBh1; RpIILS; RPO2; RPOL2
- translate.label.attr.clone:
- CTD4H8
- Clonality:
- Monoclonal
- Extra Details:
- RNA polymerase II (Pol II) is an enzyme that is composed of 12 subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter; thereby allowing transcription to begin. The largest subunit of Pol II (referred to as RPB1 or RPB205) is a 1;840 amino acid protein that contains one C2H2-type zinc finger and a C-terminal domain comprised of several heptapeptide repeats. Althoµgh Pol II function requires the cooperation of all twelve subunits; the largest subunit conveys Pol II catalytic activity and; together with the second largest subunit; forms the active center of the Pol II enzyme. Additionally; the large subunit participates in forming the DNA-binding domain of Pol II; a groove that is necessary for transcription of the DNA template. Without proper function of the large subunit; mRNA synthesis and subsequent transcription elongation cannot occur.
- Host:
- Mouse
- Immunogen:
- Ten repeats of synthetic peptide YSPTSPS using chemically synthesized phospho-Ser5
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
