Anti-Geminin / DNA Replication Inhibitor Monoclonal Antibody(Clone: CPTC-GMMN-1)
Product Sizes
20 µg
£397.00
36-2902-20UG
100 µg
£716.00
36-2902-100UG
About this Product
- SKU:
- 36-2902
- Additional Names:
- DNA replication inhibitor; Gem; Geminin DNA replication inhibitor; GMMN; RP3 369A17.3
- translate.label.attr.clone:
- CPTC-GMMN-1
- Clonality:
- Monoclonal
- Extra Details:
- Geminin is a nuclear protein that regulates the initiation of DNA replication during the cell cycle. DNA replication requires the coordinated association of Cdc6 and minichromosome maintenance (MCM) proteins with chromatin. Geminin blocks this assembly of the MCM into the prereplication complex and; in turn; prevents replication from occurring. Expression of Geminin fluctuates throµghout the cell cycle with Geminin levels lowest at G1. Throµghout S; G2 and M phases; Geminin levels are consistently elevated followed by a decrease during mitosis. The initiation of DNA replication is dependent on the degradation of Geminin during mitosis and the absence of Geminin throµghout G1 phase. Geminin degradation is mediated by the anaphasepromoting complex (APC); which specifically targets B-type cyclins and other proteins containing a destruction box motif for degradation by ubiquitinmediated proteolysis. While geminin expression is essential in maintaining chromosomal integrity; it is frequently overexpressed in cancers and evidence sµggests that it plays a significant role in tumor proliferation and progression.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length protein
- Isotype:
- Mouse IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
