Anti-PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Monoclonal Antibody(Clone: PAPPA/2716)
Product Sizes
20 µg
£397.00
36-2893-20UG
100 µg
£716.00
36-2893-100UG
About this Product
- SKU:
- 36-2893
- Additional Names:
- ASBABP2; Aspecific BCL2 ARE binding protein 2; Differentially placenta 1 expressed protein; DIPLA1; IGF-dependent; IGFBP4ase; Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGFBP-4 protease); PAPA; PAPP A; PAPPA1; Pappalysin-1; Pregnancy Associated Plasma Protein A (PAPP-A)
- translate.label.attr.clone:
- PAPPA/2716
- Clonality:
- Monoclonal
- Extra Details:
- Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses; althoµgh it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta; which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs); IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF; whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thoµght to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been sµggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been sµggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary)
- Isotype:
- Mouse IgG2b; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
