Anti-8-Oxoguanine DNA Glycosylase Monoclonal Antibody(Clone: CPTC-OGG1-1)
Product Sizes
20 µg
£397.00
36-2886-20UG
100 µg
£716.00
36-2886-100UG
About this Product
- SKU:
- 36-2886
- Additional Names:
- HMMH; HOGG1; MUTM; OGH1
- translate.label.attr.clone:
- CPTC-OGG1-1
- Clonality:
- Monoclonal
- Extra Details:
- 8-oxoguanine (8-oxoG); an oxidized form of guanine; is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversionmutations; because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase); also designated MMH; is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype; characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes eight isoforms (OGG1A-C; OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus; whereas the OGG2A splice variant is targeted to the mitochondria. Guanine is the main target for reactive oxygen species in DNA; and 8-oxoguanine is the most frequent base lesion. Therefore; formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1. Furthermore; defects in OGG1 may be a cause of renal cell carcinoma.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human OGG1 protein
- Isotype:
- Mouse IgG2c; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
