Anti-CD73 (Immuno-Oncology Target) Monoclonal Antibody(Clone: NT5E/2646)
Product Sizes
20 µg
£397.00
36-2879-20UG
100 µg
£716.00
36-2879-100UG
About this Product
- SKU:
- 36-2879
- Additional Names:
- 5' NT; 5' nucleotidase (CD73); 5' nucleotidase precursor; 5' nucleotidase; ecto; 5' nucleotidase; ecto (CD73); E5NT; Ecto 5' nucleotidase; Ecto-5'-nucleotidase; eN; eNT; NT; NT5; NT5E; NTE; Purine 5 Prime Nucleotidase
- translate.label.attr.clone:
- NT5E/2646
- Clonality:
- Monoclonal
- Extra Details:
- CD73 is a membrane-bound extracellular enzyme overexpressed in several cancer types. Its expression has been linked to poor prognosis in melanoma; colorectal; gastric; triple negative breast cancer; and to a pro-metastatic phenotype in prostate cancer. Together with CD39; it plays a major role in promoting immunosuppression throµgh the pathway degrading adenosine triphosphate (ATP) into adenosine. Within the tumor microenvironment; ATP promotes immune cell-mediated killing of cancer cells. In contrast; adenosine accumulation causes immune suppression; dysregulation of immune cell infiltrates and stimulates angiogenesis resulting in tumor spreading. CD73 is active on the last step of the degradation pathway; where it is the enzyme that actually degrades AMP into adenosine. CD73-blockade promotes anti-tumor immunity by reducing adenosine accumulation. Accordingly; anti-CD73 mAbs stimulate anti-tumor immunity and reduce tumor metastasis in Mouse tumor models; and could enhance the efficacy of treatment with anti-PD1 or anti-CTLA4 antibodies.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human NT5E protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
