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Antibodies

Anti-CD73 (Immuno-Oncology Target) Monoclonal Antibody(Clone: NT5E/2503)

Product Sizes
20 µg
£397.00
36-2876-20UG
100 µg
£716.00
36-2876-100UG
About this Product
SKU:
36-2876
Additional Names:
5' NT; 5' nucleotidase (CD73); 5' nucleotidase precursor; 5' nucleotidase; ecto; 5' nucleotidase; ecto (CD73); 5'-NT; 5'-nucleotidase; 5NTD_HUMAN; CD73; CD73 antigen; E5NT; Ecto 5' nucleotidase; Ecto-5'-nucleotidase; eN; eNT; NT; NT5; NT5E; NTE; Purine 5 Prime Nucleotidase
translate.label.attr.clone:
NT5E/2503
Clonality:
Monoclonal
Extra Details:
CD73 (also designated ecto-5'-nucleotidase; E5NT; NT; NT5; NTE; eN and eNT) is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins; CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants; yet elicits diverse biological function throµgh differential regulation in endothelial cells (EC); subpopulations of B and T cells; germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example; IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC; and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore; IgG-mediated targeting of lymphocyte CD73; but not of endothelial cell CD73; causes shedding of CD73 and tyrosine phosphorylation of proteins.
Host:
Mouse
Immunogen:
Recombinant full length human NT5E protein
Isotype:
Mouse IgG1; kappa
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig. 2: Formalin-fixed; paraffin-embedded human Lung Carcinoma stained with CD73 Mouse Monoclonal Antibody (NT5E/2503).
Fig. 3: Formalin-fixed; paraffin-embedded human Prostate Carcinoma stained with CD73 Mouse Monoclonal Antibody (NT5E/2503).
Fig. 4: Formalin-fixed; paraffin-embedded human Colon Carcinoma stained with CD73 Mouse Monoclonal Antibody (NT5E/2503).
Fig. 4: Formalin-fixed; paraffin-embedded human Colon Carcinoma stained with CD73 Mouse Monoclonal Antibody (NT5E/2503).
Fig. 5: Immunofluorescence staining of U87MG cells using CD73 Mouse Monoclonal Antibody (NT5E/2503) followed by goat anti-Mouse IgG conjµgated to CF488 (green). Membrane stained with Phalloidin (Red).