Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody(Clone: NPM1/3285)
Product Sizes
20 µg
£397.00
36-2867-20UG
100 µg
£716.00
36-2867-100UG
About this Product
- SKU:
- 36-2867
- Additional Names:
- NO38; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin (nucleolar phosphoprotein B23 numatrin); Nucleophosmin; Nucleophosmin/nucleoplasmin family member 1; Numatrin
- translate.label.attr.clone:
- NPM1/3285
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a 33kDa glycoprotein; identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thoµght to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners; in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody may be a useful aid for classification of acute myeloid leukemia.
- Host:
- Mouse
- Immunogen:
- Recombinant human NPM1 protein fragment (aa185-287) (exact sequence is proprietary)
- Isotype:
- Mouse IgG2c; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
