Anti-NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) Monoclonal Antibody(Clone: NKX61/2561)
Product Sizes
20 µg
£397.00
36-2862-20UG
100 µg
£716.00
36-2862-100UG
About this Product
- SKU:
- 36-2862
- Additional Names:
- Homeobox protein NK-6 homolog A; NK homeobox; family 6; A; NK6 homeobox 1; NK6 transcription factor homolog A; NK6 transcription factor related; locus 1 (Drosophila); NKX6-1; NKX6A
- translate.label.attr.clone:
- NKX61/2561
- Clonality:
- Monoclonal
- Extra Details:
- Members of the Nkx family of homeodomain proteins are key regulators of growth and development in several tissues; including brain; heart and pancreas. During neural development; sonic hedgehog (Shh) is known to control cell fate and mitogenesis; which is correlated with Shh dose-dependent expression of several genes; including Nkx-6.1. Specifically; Nkx-6.1 is responsible for cellular differentiation in the ventral neural tube and spinal meninges in response to Shh. In the pancreas; Nkx-6.1 is exclusively expressed in the islets of Langerhans in differentiating and mature B cells; which produce Insulin. The presence of Pdx-1 is required for the expression of Nkx-6.1 as well as other pancreatic B cell specific genes; including Insulin; Glut2 and IAPP. Subsequently; Nkx-6.1 binds to the DNA consensus sequence; TTAATTAC; to direct the repression of specific genes in B cells. Nkx6.1 is highly expressed in pancreatic and duodenal well-differentiated neuroendocrine tumors (WDNETS) and in metastatic WDNETS; is a highly specific marker of tumors of pancreatic origin. It has thus been sµggested that Nkx6.1 is a useful inclusion into IHC panels for identifying primary sites of WDNETS.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human NKX6.1 protein
- Isotype:
- Mouse IgG2c; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
