Anti-NKX3.1 (Metastatic Prostate Adenocarcinoma Marker) Monoclonal Antibody(Clone: NKX3.1/2836)
Product Sizes
20 µg
£397.00
36-2859-20UG
100 µg
£716.00
36-2859-100UG
About this Product
- SKU:
- 36-2859
- Additional Names:
- NK3 Homeobox 1; Homeobox Protein NK-3 Homolog A; NKX3-1; NKX3A; NK3 Transcription Factor Related; Locus 1 (Drosophila); NK3 Transcription Factor Related; Locus 1; NK Homeobox (Drosophila); Family 3; A; NK3 Transcription Factor Homolog A; NK Homeobox; Family 3; A; Homeobox Protein Nkx-3.1; BAPX2; NKX
- translate.label.attr.clone:
- NKX3.1/2836
- Clonality:
- Monoclonal
- Extra Details:
- NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2; which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore; NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This sµggests that immunohistochemical staining of NKX3.1; along with other prostate-restricted markers; may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 92-224) of human NKX3.1 protein (exact sequence is proprietary)
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
