Anti-MUC1 / CA15-3 / EMA / CD227 (Epithelial Marker) Monoclonal Antibody(Clone: MUC1/2818R)
Product Sizes
20 µg
£397.00
36-2817-20UG
100 µg
£716.00
36-2817-100UG
About this Product
- SKU:
- 36-2817
- Additional Names:
- Breast carcinoma-associated antigen DF3; CA15-3; H23AG; KL-6; MAM6; Mucin 1 cell surface associated; ; Peanut-reactive urinary mucin; PEM; PEMT; Polymorphic epithelial mucin; Tumor-associated epithelial membrane antigen
- translate.label.attr.clone:
- MUC1/2818R
- Clonality:
- Monoclonal
- Extra Details:
- This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium; including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in 90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
- Host:
- Rabbit
- Immunogen:
- Human milk-fat globule membranes (HMFGM)
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
