Anti-MTAP (Tumor Suppressor Marker) Monoclonal Antibody(Clone: MTAP/3137R)
Product Sizes
20 µg
£397.00
36-2806-20UG
100 µg
£716.00
36-2806-100UG
About this Product
- SKU:
- 36-2806
- Additional Names:
- BDMF; DMSFH; DMSMFH; Epididymis luminal protein 249; HEL249; LGMBF; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAPase; S-methyl-5''-thioadenosine phosphorylase
- translate.label.attr.clone:
- MTAP/3137R
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 31kDa; which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine; which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene; p16INK4A. Deficient levels of MTAP can occur in cancers primarily throµgh co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates); whose mechanism of action; in part; involves this de novo purine pathway.
- Host:
- Rabbit
- Immunogen:
- Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary)
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
