Anti-MMP3 (Marker of Metastasis and Rheumatoid Arthritis) Monoclonal Antibody(Clone: 1B4)
Product Sizes
20 µg
£397.00
36-2788-20UG
100 µg
£716.00
36-2788-100UG
About this Product
- SKU:
- 36-2788
- Additional Names:
- CHDS6; Matrix metalloproteinase 3; Matrix metalloproteinase-3; MMP3; Proteoglycanase; SL1; STMY1; STR1; Stromelysin-1; Transin 1
- translate.label.attr.clone:
- 1B4
- Clonality:
- Monoclonal
- Extra Details:
- The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components; including collagen; gelatin; fibronectin; laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester; lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3; MMP-10 and MMP-11 (also designated stromelysin-1; 2 and 3; respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine; and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment corresponding to amino acids 317-327 of human MMP3.
- Isotype:
- Mouse IgG1; lambda
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
