Anti-Microphthalmia Transcription Factor (MITF) Monoclonal Antibody(Clone: MITF/2987R)
Product Sizes
20 µg
£397.00
36-2770-20UG
100 µg
£716.00
36-2770-100UG
About this Product
- SKU:
- 36-2770
- Additional Names:
- BHLHE32; Class E basic helix-loop-helix protein 32 (bHLHe32); CMM8; Mi; Microphthalmia-associated transcription factor; MITF; WS2; WS2A
- translate.label.attr.clone:
- MITF/2987R
- Clonality:
- Monoclonal
- Extra Details:
- MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium; and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation; resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition; Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist; including MITF-A; MITF-B; MITF-C; MITF-H; and MITF-M; which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. This MAb recognizes a nuclear protein; which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes; benign nevi and dysplastic nevi.
- Host:
- Rabbit
- Immunogen:
- Recombinant full-length human MiTF protein
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
